教学目的、要求
预修课程
教材
主要内容
Course description: Lectures will cover the key concepts of population genetics, starting from simple models of random mating populations, then considering the complications of genetic drift, structured populations and inbreeding, mutation and migration, and natural selection. We will then apply these principles to the case studies of the population genetics of DNA and protein sequence variation within and between species. We integrate the lecture, text readings, problems, and discussion sections together so as to keep you on top of the material, and to help you evaluate your comprehension of the material. Lecture contents: 1 . (6/25, Monday) Genetic variation and random mating 1. Variation: morphology, karyotype, proteins, DNA 2. Organization of genetic diversity -- basic models a. Hardy-Weinberg: Random mating populations b. Estimating allele frequencies; testing H.W. c. Single locus extensions including sex linkage d. Extension to two loci: linkage disequilibrium 3. An application: DNA fingerprinting 2 . (6/26, Tuesday) Finite population size and genetic drift 1. Binomial sampling and drift within populations 2. Consequences of drift among populations 3. Identity by Descent and the coalescent process 4. Effective population size: concepts and estimation 3 . (6/27, Wednesday) Mutation 1. Mutation - estimation and role as an evolutionary force 2. Mutation and drift a. Infinite allele and infinite site models b. Linkage disequilibrium 4 . (6/28, Thursday) Natural Selection 1. Basic models - asexual/haploid models, sexual/diploid models 2. Estimation of selection coefficients 3. Sex linkage, multiple alleles and varying fitness 4. Selection models continued 5. Multilocus selection and epistasis 6. Selection and drift 7. Selection and mutation: infinite and finite populations 5 . (7/2, Monday) Nonrandom mating 1. Inbreeding a. Effects on genetic variation b. Estimation of inbreeding coefficients 2. Asexual reproduction and Assortative mating 6 . (7/3, Tuesday) Migration and structured populations 1. Models of migration 2. Migration and drift 3. Wahlund’s Principle; effects on linkage disequilibrium 4. Measures of population differentiation and estimation of migration 5. Selection and migration in structured populations 7. (7/4, Wednesday) Introduction of molecular population genetics and case studies