教学目的、要求
Malignant tumors remain a major health burden throughout the world and new strategies are urgently needed to treat them effectively. Cancer nanotechnology has the potential to dramatically improve current approaches to cancer detection, diagnosis, imaging, and therapy while reducing toxicity associated with traditional cancer therapy. The application of nanotechnology to developing safer and more effective antitumor nanomedicine have so far proven to be both evolutionary and revolutionary and will eventually revolutionize the current landscape of cancer therapy. The multidisciplinary nature of nanomedicine requires integration of cancer biology, clinical oncology, chemistry, physics, materials science, biomedical engineering, toxicology, computer science, and mathematics to achieve the vital goals of nanotechnology-mediated early cancer detection and more efficacious and less toxic therapies for cancer. In this course, the fundamental sciences related to cancer nanotechnology in both cancer biology and Nanoscience and technology will be covered. The issues related to preclinical and clinical applications of nanotechnology for cancer diagnosis and therapy will also be discussed. Some key methodological approaches in cancer nanotechnology and subject will also be outlined. This course will be helpful for graduate students to get an overall picture about the current landscape of nanotechnology integrated into the current tumor biology and clinical oncology.
预修课程

教材
Recommended books: Among the several books on the list of cancer nanotechnology, there are a few books with different focuses. For a general understanding of the cancer nanotechnology, the book “Nanotechnology and Oncology: Workshop Summary” is available. If you have great interest in this area Cancer Nanotechnology: Nanomaterials for Cancer Diagnosis and Therapy is recommended. However, if you are going to do your own research on the cancer nanotechnology, the “Cancer Nanotechnology: Methods and Protocols” will be helpful to provide some hands experience.
主要内容
Session one: Fundamentals of Cancer Nanotechnology 1. Introduction of the course 2. Cancer Biology. Fundamental cancer biology and the recent progress on tumor cells and their microenvironment will be introduced. 3. Clinical Oncology. Clinical pictures of major malignant tumors (including breast cancer and liver cancer) and the major therapeutic strategies will be covered. The major challenges of current clinical treatment of cancer will also be discussed. 4. Preclinical and clinical antitumor drug development. 5. Cancer nanotechnology. When cancer biology and medicine meet nanotechnology, some unique biochemical and physiological mechanisms of cancer biology will be applied to tumor therapy and diagnosis, such as passive and active targeting and co-delivery strategy. Some new nanoscale mechanisms of cellular functions relevant to cancer will be discussed. 6. Issues of Nanotoxicity in antitumor drug discovery. One of major barriers to overcome for developing nanomedicine is the nontoxic issues related with the nanomaterials. Some fundamental concepts of nanotoxicology will be covered in this chapter. Session two: Nanomaterials for Cancer therapy and Diagnosis 7: Why nanomaterial platforms will be good for cancer therapy and imaging? Overview of the major progress of nanotechnology for cancer disgnosis and therapy and major nanomaterials using and developing for nanomedicine will be discussed. 8. Polymeric nanoparticle system for cancer therapy and diagnosis. 9. Inorganic nanomaterials for cancer therapy and diagnosis. 10. Biomolecules-based nanoparticles for cancer therapy and diagnosis. 11. hybrid nanomaterials for cancer therapy and diagnosis. Session three: Recent Progress and invited talks Recent progress on cancer biology, clinical oncology and invited lectures will be delivered by world-renowned academic and industrial researchers based on the availability of time and speakers.