教学目的、要求
帮助一年级研究生了解分子生物学的基本内容、基本思维方式和研究方法，为其今后的研究工作提供必要的背景知识。学习过程中采用优秀教科书结合最新文献的阅读，充分发挥同学学习的主动性，有效利用课堂时间，帮助同学从本课程中学到一定的知识。 本课程为生物学各专业研究生的学科基础课，也可作为相关学科研究生的选修课。细胞分子生物学是当今生物学的核心及最活跃的前沿所在。本课程将以细胞世界内的物质流、信息流及能量流为基本框架，介绍相关的分子事件及前沿动态。通过本课程的学习，希望学生能够基本掌握细胞分子生物学的梗概内容，为今后的研究工作打下基础。
预修课程

教材

主要内容
内容提要: 1. 什么叫分子生物学 对学生分子生物学知识和阅读内容的简单调查 介绍3本书 通过书本中的内容，谈对分子生物学的体会：概念，思维方式，研究技术 介绍为什么要用新的方式组织本课程的教学 分组 2. Cells and Viruses-Overview Biomembranes The Nucleus Organelles in the Cytoplasm Viruses Bacteriophages Anthrax and Biological Weapons 3. Protein Structure and Function Building Block-Amino Acids Peptide, Secondary Structure and Three-Dimensional Structure Enzymes: classification of enzymes and catalytic mechanisms of enzymes Membrane proteins Miscellaneous proteins 4. Nucleic acid, genomics and proteomics Building block-nucleotides DNA structure,RNA structure and chromatin structure The genetic code and genes Genomics and proteomics 5. Gene transcription Overview of gene expression and transcription Gene’s regulatory elements Transcription mechanism in prokaryotes Transcription mechanism in eukaryotes Motif structures of transcription factors Histone acetylation and DNA methylation Regulation of transcription factors Transcription of RNA genes Genomic replications of viruses 6. Posttranscriptional processes RNA processing: RNA splicing and RNA editing Nuclear transport Synthesis of proteins Sorting of proteins Synthesis of lipids 7. Cell signaling and apoptosis Overview Signaling via hydrophobic molecules Signaling via ion channels Signaling via G-protein-coupled receptors Signaling via cell surface enzymes Intracellular signaling Apoptosis 8. DNA replication, mutation and repair Overview of DNA replication Mechanism of DNA replication Telomerase and aging Topoisomerases Mutation and consequences Mutation mechanism DNA repair mechanisms 9. Cell division and system development Cell cycles: initiation and termination mechanism of the S phase Mitosis DNA recombination Chromosome abnormality Mechanisms of development Formation of tissues The immune system 10. Biotechnology and bioinformatics DNA cloning: DNA recombination technology and cloning vectors Genomic library and cDNA library Gel electrophoresis Blotting methods and applicatons Polymerase chain reacton (PCR) DNA sequencing Site-directed metagenesis Production of recombinant proteins Organism cloning Bioinformatics 11. Genes and disease Gene mapping Cloning disease genes Cancer Alzheimer’s disease Obesity and diabetes